Negative Results Matter: Why Can't We Improve the Treatment of Proliferative Vitreoretinopathy?
نویسندگان
چکیده
منابع مشابه
Proliferative vitreoretinopathy.
PURPOSE. The migration, proliferation, differentiation, and adhesion of cells and other cellular functions are influenced by the surrounding extracellular matrix, in normal and wound-healing conditions. The matrix metalloproteinases (MMPs) are a family of enzymes that degrade and remodel the extracellular matrix and, thus, play a central role in the wound-healing process. Proliferative vitreore...
متن کاملEvaluation of retinectomy in the treatment of severe proliferative vitreoretinopathy
BACKGROUND To evaluate the postoperative results and efficacy of retinectomy in the treatment of severe proliferative vitreoretinopathy (PVR). METHODS The study involved 38 individuals with rhegmatogenous retinal detachment initially diagnosed with PVR grade C3 who had undergone pars plana vitrectomy combined with scleral buckle and silicone oil as a tamponade. A standard three-port pars plan...
متن کاملThe Pathogeny of Proliferative Vitreoretinopathy.
Proliferative vitreoretinopathy (PVR) is the most important complication of rhegmatogenous retinal detachment (RRD) and the main cause of RRD surgery failure. This is a review of recent literature data, which concerns PVR pathogeny and risk factors. The occurrence of pre- and subretinal membranes is a consequence of retinal pigment epithelial cells activation and migration, with concomitant par...
متن کاملAclacinomycin A in the Treatment of Experimental Proliferative Vitreoretinopathy
Methods. Dutch-belted rabbit were used to create a model for traction retinal detachment. Seven to 10 days after vitreous gas compression, 25,000 homologous fibroblasts were injected into the vitreous cavity. Subsequently, the eyes received either sham injections or doses of 6, 30, or 60 nmol of aclacinomycin A, respectively. The fundus findings were documented on days 7, 14, and 28 after the f...
متن کاملUse of perfluorocarbon liquids in proliferative vitreoretinopathy: results and complications.
BACKGROUND The present study was set up to evaluate the influence of perfluorocarbon liquids on the postoperative anatomical and functional results as well as on the complication rates in eyes with proliferative vitreoretinopathy (PVR). METHODS Sixty five consecutive eyes (64 patients) with PVR in different stages requiring surgical intervention where liquid perfluorocarbons were used were co...
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ژورنال
عنوان ژورنال: Ophthalmology
سال: 2017
ISSN: 0161-6420
DOI: 10.1016/j.ophtha.2017.02.020